Trodusquemine: Unpronounceable Drug That Can Reverse Heart Disease With One Dose

Josephine Thompson

Journalist

Trodusquemine already works as a for treatment of breast cancer and diabetes. However, scientists at Aberdeen University have found out it can have benefits to your cardiovascular health too. Just one dose reversed atherosclerosis, a disease that causes heart attacks and strokes, in mice. Their arteries were cleaned of plaques of fatty substances that narrow down the blood vessels.

Researchers think that the drug activates a protective enzyme just like exercise would, and inhibits an inflammation and hardening of arteries-causing enzyme. "We know this drug has been shown to have beneficial effects on reducing prolonged inflammation in type 2 diabetes and because this is also a factor in atherosclerosis, we wanted to know if it had cardiovascular benefits too," said study lead professor Mirela Delibegovic from the University of Aberdeen’s Institute of Medical Sciences. "And our initial tests on mice show that it does, so this is potentially a big breakthrough." source

"Essentially, when it comes to the key enzymes in play here, trodusquemine is stopping the bad guy and helping the good guy. We will now need to carry out further research to see if the same effect is replicated in humans and it can be proven to be safe." Trodusquemine stops PTP1B enzyme, found in increased quantities in people suffering from obesity or diabetes. This little bugger also has hands in inflammation related conditions such as sepsis, inflamed diabetic foot ulcers and allergic lung inflammation.

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Atherosclerotic plaque formation has been linked to the presence of this enzyme. Therefore, the drug was tested on mice genetically modified to have the disease. Regular and even singular doses of the trodusquemine helped clear out the mousey arteries. It also worked to stimulate AMPK, a protein that reduces chronic inflammation.

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"We all have fatty arteries," said professor Delibegovic. "We all have these fatty streaks in our arteries to some degree and as we age atherosclerosis is accelerated. Eating sugary and fatty foods contribute to this process which is why the disease is a big problem for people who are overweight."

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When the arteries harden and narrow because of the fatty plaques, it restricts the blood flow and oxygen supply to organs – and blood clots can stop the flow completely. Reduced or blocked flow of blood to the heart can lead to chest pain, discomfort and heart attack.

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